Abstract
We have recently reported that β-nicotinamide adenine dinucleotide (β-NAD) is released during electrical field stimulation (EFS) of canine isolated mesenteric arteries and veins and urinary bladder detrusor smooth muscle of mouse, rat, guinea-pig, rabbit, monkey, and human (Smyth et al., J Biol Chem 279:48893, 2004; Breen et al., Am J Physiol 290:F 486, 2006). Exogenous β-NAD reduces the release of norepinephrine, causes vasorelaxation in canine mesenteric blood vessels, and inhibits the spontaneous contractions in murine and human bladders.
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