Abstract
Aim. To study the influence of triphenyltetradecylphosphonium bromide [(PPh) 3P +C 14H 29] Br on the cell membranes permeability to Na + by determining the rate of Na +-Li +-counter transport in erythrocyte membrane depending on it’s variable initial condition. Methods. Blood samples of 10 healthy volunteers with different Na +-Tі +-counter transport rate distribution in erythrocyte membrane were analyzed: I quartile (5 subjects) — low permeability, III quartile (5 subjects) — moderately high permeability. Results. Na+-Li+-counter transport rate change in erythrocyte membrane under the influence of triphenyltetradecylphosphonium bromide depends on genetically determined initial membrane permeability. In subjects belonging to III quartile of Na +-Li +-counter transport the initial membrane permeability is high, and after administration of 0.001 and 0.005 μΜ concentrations of [(PPh) 3P +C 14H 29] Br membrane permeability to Na + increased. In subjects belonging to I quartile of Na +-Tі +-counter transport (low initial permeability) [(PPh) 3P +C 14H 29] Br did not alter membrane permeability to Na +. Conclusion. Triphenyltetradecylphosphonium bromide increases erythrocyte membrane permeability to Na + in subjects belonging to III quartile of Na +-Li +-counter transport and dose not influence subjects belonging to I quartile of Na +-Tі +-counter transport.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
