Abstract
The synthesis and pharmacological properties of the new taurine amide derivative, N-(l-metyl-2-phenylethylamino)ethanesulfonic acid isopropilamide hydrochloride, are described. Pronounced antiarrhythmic properties have been observed on animals with experimental ventricular arrhythmias (early postocclusive and calcium chloride models). The drug significantly decreased the frequency and intensity of paroxysmal tachycardia attacks and ventricular fibrillation after coronary artery occlusion. Simultaneous use of calcium chloride and N-(1-metyl-2-phenylethylamino)ethanesulfonic acid isopropilamide hydrochloride increased the arrhythmogenic dose of calcium chloride inducing the heartbeat disorders and asystolia and decreased the frequency of ventricular flutter and fibrillation. The antiarrhythmic effect of the drug was similar to that of lidocaine. The antifibrillatory activity is the most important manifestation of the antiarrhythmic action of the taurine derivative studied. These data suggest that N-(l-metyl-2-phenylethylamino)ethanesulfonic acid isopropilamide hydrochloride is а potential drug for urgent aid in myocardial infarction.
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