Abstract
Reactions of the polyene macrolide antibiotic amphotericin B with aromatic benzaldehydes and sodium cyanoborohydride under the conditions of reductive amination resulted in the formation of N-benzyl derivatives. Physicochemical and biological properties of the synthesized derivatives of amphotericin B have been studied. N-Benzyl derivatives showed high antifungal activity against а large number of test cultures. The biological tests showed that the acute toxicity (LD50) of amphotericin B derivatives was 3 times lower as compared to the initial antibiotic.
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