Abstract

Abstract To maintain a negative pressure, the supply, exhaust airvolume are adjusted by setting volume damper and theinfiltration through leakage area of the door between rooms in biosafety laboratory. Multizone simulation is useful way topredict room pressure, supply and exhaust air volume. But in a particular room, local change such as airflow and contaminantsconcentration distribution can not be evaluated unfortunately. Through this study, a coupled multizone and CFD simulation was performed, indoor air flow and local contaminants con-centration distribution in a particular room of BSL lab are predicted. The results show that all zones of BSL lab are wellventilated by unidirectional flow without local stagnation. In addition, in case that unexpected biohazard is occured in BSLlab, multizone simulation results about the spread of pollutants along movement of the occupant also show that contaminantsconcentration is removing totally without the spread of the outside. In conclusion, a coupled multizone and CFD simulationcan be applied to interpret differential pressure in room and local change of physical quantity in a particular room suchas airflow and Influenza A contaminants concentration distribution. This simulation method is useful to enhance the reliabilityand accuracy of biosafety laboratory design.

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