Abstract
MMP9 is deeply involved in invasion, metastasis and angiogenesis of various tumors, and can also affect the tumor microenvironment. The aim of this study was to analyze the MMP9 levels in tissues with independent and com- bined growth (MPT): B16/F10 melanoma and Lewis lung carcinoma. Primary immunodeficiency presented in a model of Balb/c Nude mice was chosen as a comorbid pathology. The study included 24 females divided into groups (n=6 each): 1 – intact animals, 2 – animals with B16/F10 melanoma, 3 – animals with Lewis lung carcinoma (LLC), 4 - ani- mals with a combination of B16/F10 and LLC - multiple primary malignancies (MPMs). Levels of MMP9 were measured by ELISA in homogenates of tumor and perifocal tissues in all animals. In animals with MPT, levels of MMP9 in B16/ F10 were 3.9 times higher than in LLC, and the levels in B16/F10 perifocal tissues were 1.9 times higher than in LLC perifocal tissues. MMP9 in non-cancer tissues in animals with MPT 2.8 times exceeded the levels in intact animals. In animals with MPT, MMP9 in tumor samples positively correlated with the primary node volumes. Whatever the level of MMP9 in the tumor and perifocal tissues, it is clearly directly involved in cancer development.
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