Abstract
The physiological response to wounding is the development of an inflammatory cell infiltrate. Excessive response may lead to scar tissue development. Of interest to investigators examining leukocyte migration is the ability to enumerate in-vitro cellular movement in migration assays. The ability of the immunomodulator α1-acid glycoprotein (AGP) to influence leukocyte transendothelial migration was investigated using a Trans-well system. Leukocytes migrated towards human synovial fibroblasts in response to transforming growth factor β and tumour necrosis factor α in an in-vitro model of the cellular processes involved in tendon healing. The Optimas image analysis programme was used to enumerate leukocyte migration in the presence of AGP derived from normal plasma and from inflammatory exudate. The ability of inflammatory derived AGP to significantly reduce leukocyte transendo-thelial migration in the tendon healing model was demonstrated by Optimas image analysis.
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