水頭症を併発せず治癒した<I>Flavobacterium meningosepticum</I>による新生児髄膜炎の1例

Abstract

This paper reports a case of neonatal meningitis caused by Flavobacterium meningosepticum, recovered without hydrocephalus. Five day old boy with apneic episodes was transfered to our hospital from a obsteric hospital. Pathogens were isolated from blood on admission and hospital day 4, and from cerebrospinal fluid on hospital day 5. The chemotherapy to Fravobacterum meningitis was started on hospital day 5. Minocycline (MINO), erythromycin (EM) and piperacillin (PIPC) were administered intravenously.The next day, antibiotics were changed for cefmetazole (CMZ) and lincomycin (LCM) considered possible side effects of MINO in neonate and the sensitivity of isolated pathogen to EM and PIPC, though the cerebrospinal fluid became sterile and the general condition of the patient improved. On hospital day 9, the administration of LCM was discontinued, and CMZ alone continued for 13 days. After the discontinuance of the chemotherapy, the patient was still in good condition. The enlargement of the ventricles was not ofserved in the computed tomography of the brain performed in series. At 3 month old, the patient showed normal development without abnormal neurological signs. MINO and CMZ were considered to be effective in this case from the clinical course and the minimum inhibitory concentration of these antibiotics to the isolated Fravobacterium.