Abstract
The concentration of γ- l-glutamyl- l-glutamate (γ-glu-glu), a potent displacer of excitatory amino acid receptor binding, and other structurally related dipeptides were determined in extracts of the rat olfactory bulb by a novel liquid chromatographic method. Whole-cell patch clamp recordings of currents from freshly isolated neurons showed that γ-glu-glu produced inward currents at negative holding potentials, provided μM concentrations of glycine were added and no Mg 2+-ions were present, indicating activation of N- methyl- d-aspartate receptors. Consistently, geometry optimization of γ-glu-glu using molecular mechanics calculations, suggested a bent conformer with structural features supporting this view.
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