Abstract

The influence of L-tryptophan on the pool of central neuroactive compounds under the conditions of chronic alcohol intoxication has been studied. Chronic alcohol administration led to a dysbalance in the formation of the pool of central neuroactive compounds. The most significant changes were observed in characteristics of the central dopaminergic and serotoninergic system. The intragastric introduction of L-tryptophan in a dose of 100 mg/kg under the conditions of chronic alcohol intoxication alleviated the disturbances in functioning of the serotoninergic system. Normalization of the characteristics of dopaminergic system was less pronounced.

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