γ-irradiation modulates vascular smooth muscle cell and extracellular matrix function: implications for neointimal development

Abstract

Clinical relevance γ-Irradiation has found clinical application in the prevention of vascular recurrent stenosis. Although short-term results indicate reduction of recurrent stenosis, late results are not so promising. This in vitro study interrogated the biologic effects of γ-irradiation on vascular smooth muscle cells (SMCs) and their extracellular matrix, to enable understanding of how it affects recurrent stenosis. The results are mixed: γ-irradiation does not inhibit protein synthesis, but does inhibit SMC three-dimensional migration, enhances SMC transformation to a contractile phenotype, and reduces the functional activity of matrix-associated growth factors. This provides insight into how γ-irradiation alters the biologic response of arteries after intervention.