Abstract
Inhibitory action of some food preservatives and antibiotics, nitroflazone (NFS), nitro-furylacrylic amide (NFA), chlortetracycline (CTC) and oxytetracycline (OTC), on the growth and histamine formation of Proteus morganii, the causative organism of allergy-like food poisoning, has been studied. Results obtained may be summarized as follows: 1. The growth of seven strains of the organisms occurred with essentially the same concentration of eiter NFS, NFA or CTC in nutrient broth. A single strain showed a fairy high sistance in respect to OTC. 2. The minimal growth inhibitory concentration tested in the flat-fish infusion and in the mackerel infusion were approximately the same. 3. Effect of NFS, NFA, CTC or OTC in the broth upon the formation of histamine by Proteus morganii was in parallel with that upon the growth. 4. The formation of histamine in the raw mackerel flesh suspension was inhibited by CTC, OTC or NFA in much low concentration as compared with the minimal growth inhibitory concentration of each drug. The possible replacement in microbial flora in raw flesh suspension with resistant organisms has been discussed.
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