Abstract
The bactericidal activity against S. aureus, E. coli and fungicidal activity against C. albicans of polyclonal immunoglobulins G was established. Objectives. To evaluate the bactericidal and fungicidal activity of polyclonal immunoglobulins G isolated from patients with purulent-inflammatory diseases and to analyze its relationship with the type of pathogen of the infectious process and clinical and laboratory manifestations of the disease. Material and methods. Using the developed method the ability of polyclonal immunoglobulins G isolated from 45 patients with purulent-inflammatory diseases and 16 donors was determined to have bactericidal activity against S. aureus, E. coli and fungicidal activity against C. albicans without the participation of complement and immune cells. The ratio of viable and dead bacteria was evaluated by laser scanning confocal microscopy using propidium iodide as a marker of dead bacteria.Results. It was shown that immunoglobulins G isolated from patients with purulent-inflammatory diseases and donors may have their own bactericidal activity against S. aureus, E. coli and C. albicans without participation of the complement system and immune cells, while in patients with purulent-inflammatory diseases this activity is significantly higher than in persons without purulent-inflammatory processes. The relationship between the activity of immunoglobulins against S. aureus, E. coli and C. albicans with clinical and laboratory manifestations of pyoinflammatory diseases was analyzed.Conclusion. The findings suggest the presence of mechanisms of immunoglobulins G bactericidal activity against S. aureus, E. coli and fungicidal activity against C. albicans, which is not associated with participation of the complement system and immune cells.
Highlights
Представляет интерес наличие сильной корреляции (0,6; p
The study was approved by the local ethics committee
Summary
Количество проб IgG с достоверно положительной Достоверность бактерицидной активностью различий. При исследовании связи уровня бактерицидной активности IgG с видом микроорганизма, выделенного из гнойного очага, оказалось, что у пациентов, от которых был выделен S. aureus, уровень активности иммуноглобулинов (1,8%; 0-7,2; n=17) был достоверно (p
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