二硫化炭素の代謝に関する研究 : I 二硫化炭素の人体吸入実験, とくに二硫化炭素の皮膚からの排泄

Abstract

Human experiments were performed of six volunteers with different concentrations of carbon disulfide (CS2) from 28 ppm to 52 ppm which were inhaled for 30 to 120 minutes continuously, and the CS2 concentration was kept at a constant level during the period of each experiment. Amounts of CS2 absorbed in the body and eliminated from it by the expired air, the skin and the urine were calculated. During the period of each inhalation experiment, the volunteers were free from any symptoms, except slight headache. The results are summarized as follows: 1. The proportion of CS2 concentration in the expired air to that inspired rises gradually for the first 40 minutes and reaches equilibria at 65±10 per cent. 2. When the inhalation of CO2 is discontinued, CS2 level in the expired air goes down suddenly, and the average proportion of CS2 concentration in the expired air to that in the air which has been inhaled are 18±5, 8±2 and 4±2 per cent at the interval of every 10 minutes. 3. The amount of CS2 absorbed during the inhalation is calculated to be from 15.4 mg to 29.6 mg (average 23.0 mg), of which 17.4 mg to 7.58 mg (average 4.82 mg) is eliminated by the expired air, while the amount of CS2 excreted in the urine is from 7.2γ to 37.3γ (average 16.5γ). 4. CS2 is proved to be eliminated through the skin by the amount of 36.2γ to 77.8γ. This amount is about three time as much as that by the urine.