小児感冒, 特にHVJ (Hemagglutinating Virus of Japan) 感染症に関する研究

Abstract

In order to clarify the correlationship in the antibody production against mumps virus and HVJ which was observed in the adult case of mumps, cases of HVJ infection, cases of mumps, cases immunized with both viruses, cases of cross infection, cases cross immunized with vaccine and clinical cases of various combinations of infection and immunization with vaccine were examined for the determination of the fluctuation of antibody level. As the results, the following findings were obtained.1) In the cases of HVJ infection, regardless of the past infection of mumps, no significant fluctuation in the antibody level against mumps was recognized at all, though the subjects were all children. However, in the cases inoculated with HVJ vaccine, rise in the antibody level against mumps virus was recognized in 3 out of 5 children who experienced mumps in the past.2) In the cases of mumps infection, regardless of the past infection of HVJ, no fluctuation in the antibody level against HVJ was recognized in the children, while in the adult cases of mumps, remarkable rise in the antibody level against HVJ was recognized in 1 out of 2 cases. In 2 cases of mumps who had been immunized with HVJ vaccine in the past, rise in the antibody level against HVJ was clearly recognized. Further. when children who had been immunized with HVJ vaccine in the past were immunized with mumps vaccine, rise in the antibody level against HVJ was recognized in 4 out of 7 cases. In 4 child cases who had clinically contracted mumps after the immunization with HVJ vaccine prior to the immunization with mumps vaccine, rise in the antibody level against HVJ was recognized when they were immunized with mumps vaccine.3) In view of the above, the rise in the antibody level against HVJ which was seen in the adult mumps cases was considered to be due to the fact that the antibody level acquired at the time of HVJ infection rose as a group reaction when the antibody level against mumps virus rose.4) Although numerous studies may be required in future to clarify the correlationship in the antibody production of HVJ and mumps virus, the serological diagnosis of HVJ infection in children is considered to be done far more readily almost without error when compared with that in adult cases.