Abstract
Lipid lowering therapy to reduce LDL-C level is the cornerstone to reduce the cardiovascular disease (CVD) risks, but it should not be one size fits all. Precision medicine is an emerging field that calls for individualization of treatment strategies based on characteristics unique to each patient. Over the past few years, more evidences about new treatments and which patients may benefit from them were uncovered. Therefore, the latest clinical practice guidelines provide recommendations applicable to patients with different CVD risks. Clinicians can now treat their patients individually according to the presence of cardiovascular diseases, traditional risk factors, family history, ethnicity, certain health conditions such as metabolic syndrome, chronic kidney disease, chronic inflammatory conditions, or the coronary calcium score. In addition, several genetic predictors of statin response have already been identified, which might further identify patients who are more likely to benefit from lipid-modifying therapy as opposed to those who likely will suffer from its side effects using precision medicine tools.
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