歯周疾患と Histamine との関係

Abstract

The histamine contents in gingival tissue from patients with periodontal disease were measured fluorometrically by Håkanson-Rönnberg's method, and compared with clinical findings (depth of periodontal pocket and loss of alveolar bone by X-ray photos) and histopathological findings (Listgerten & Ellegaard's classification).The following results were obtained;1. No significant correlations were found between histamine contents in gingival tissue and following clinical findings; depth of periodontal pocket and loss of alveolar bone.2. In the group of patients that were examined on the basis of clinical findings and X-ray photos, the histamine contents in gingival tissue had tendency to increase with the progression of periodontal disease.3. As the histopathological findings, the histamine contents were markedly with the degree of inflammatory cellular infilitration and the number of mast cell.It is concluded from these result that the histamine contents in gingival tissue are closely related to the process of periodontal disease and the degree of inflammatory cellular infilitration.