Abstract
The gas composition of the arterial blood and the HIF-1a expression in hippocampal neurons of rats were measured after 7-day long daily 30-minute treatment with isolated or combined permissive hypercapnia (PCO2 = 50 mmHg) and moderate hypoxia (PO2 = 90 mmHg). HIF-1a expression was increased in the hippocampus after combined, but not isolated, treatment with moderate hypercapnia and hypoxia. The hypercapnic and/or hypoxic gas composition of the inhaled air defined the corresponding gas composition of the blood. The arterial CO2 was lower in the normobaric hypoxia group compared to control, while remaining in the normocapnic range. The arterial O2 in hypercapnic hypoxia was lowered, but not as low as in isolated hypoxia. Hypercapnia, both isolated and in combination with hypoxia, lowered the blood pH and thus led to the acidosis.
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