Abstract
Phenobarbital enhanced liver γ-glutamyltransferase (GGT) in rabbit as soon as the treatment was initiated, while the activity of the enzyme in plasma remained unchanged until Day 18 of treatment. In vitro solubilization of GGT from liver plasma membranes of controls and rabbits treated with phenobarbital showed that the longer phenobarbital was administered, the more enzyme was solubilized and the more rapidly it did so. Moreover effects of different bile salts upon the solubilization of the enzyme showed that lithocholate, a monohydroxy bile salt, and deoxycholate, a dihydroxy one, removed GGT more easily than did the trihydroxy bile salt, cholate. Our results suggest that induction and enhancement of solubilization of the enzyme after phenobarbital treatment and the effects of bile salts upon the liver membranes could provide an explanation for the increase of GGT in plasma.
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