Abstract
Abstract Mangiferin-loaded F127/PEG micellar systems were evaluated regarding the effect of PEG addition at different molecular weights, where the system with best mangiferin solubility response (0.5 wt% of PEG in 1 wt% F127 aqueous solution) was chosen to be a potential drug delivery system (DDS), which solubilized 7.92 mg dL−1 of mangiferin. Subsequently, the chosen mangiferin-loaded DDS was evaluated in regard the inhibition of enzyme α-glucosidase, which showed a more effective inhibition, around 95.42%, when compared to the standard acarbose (92.59%) and to the free-form mangiferin (90.42%). The same micellar system was also evaluated for its cytotoxicity, where no significative values of LDH activity was observed. No study has been done yet with both mangiferin and DDSs regarding in vitro α-glucosidase inhibitory activity. This work proposes a “new” alternative towards diabetes treatment.
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