Abstract
The α-fluorophosphonocarboxylate analogs of bisphosphonates have recently received attention due to their activity against Rab geranylgeranyl transferase, an enzyme implicated in a number of disease conditions. Most of the NMR data reported in the literature describing dialkyl α-fluorophosphonates are defined as first-order spectra. Here, we report a second-order pattern observed in 19F NMR spectrum, being a part of heteronuclear ABMX spin system. Such a spin system, CH2C(F)P, was subjected to NMR analysis supported by iteration.
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