Abstract
In advanced atherom atherosclerosis, a large amount of lipids, particularly cholesterol esters, accumulates on the arterial wall. The selective removal of cholesterol esters accumulated in the intra-cellular or extracellular spaces has clinical significance. In the present work we investigate the removal of cholesterol esters by using a free electron laser (FEL). Thin films of cholesterol oleate and albumin were placed on an inverted microscope stage and the changes caused by the FEL irradiation of 5.75μm and 6.1μm with 1.5-3mW in average were monitored continuously by a CCD camera in real time. FEL irradiation at a wavelength of 5.75μm, which is a stretching bibrational mode of the ester, was able to ablate cholesterol esters without affecting albumin and that it can also remove cholesterol esters from rabbits' arteriosclerotic arterial walls.
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