Abstract
Benzothiadiazole (BTD) is one of the popular compounds for organic electronic devices, organic synthesis, and fluorescent probes. Here, benzothiadiazole derivatives were successfully synthesized by heck coupling reaction, which exhibited the the advantages of simplicity and efficiency, wild substrate csope, easily available substrates and high yield. The fluorescent probe BTDAr-PEG targeting lipid droplets was successfully prepared by the nucleophilic substitution reaction between the heck coupling reaction product 3h and Amino polyethylene glycol monomethyl ether (Mn=2000). BTDAr-PEG exhibited the advantages of high selectivity, good stability and pH resistance. The use of PEG as a substrate gave BTDAr-PEG good biocompatibility. It was worth mentioning that BTDAr-PEG could not only track LDs in cells under different physiological conditions, but also distinguish between living and dead cells in biological systems.
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