Abstract
With a view to the development of oral controlled drug delivery systems (DDS), new interpolyelectrolyte complexes (IPECs) between oppositely charged types of Eudragit ЕРО and Eudragit L100 have been investigated. Structural features of the samples were evaluated by modulated-temperature differential scanning calorimetry (MTDSC). The obtained data confirm that all polycomplexes are chemically homogenous and characterized by only one glass transition temperature. Evaluation of the diffusion transport properties of investigated IPECs revealed basic mechanisms responsible for the controlled delivery of drugs with different physicochemical properties. The results show that the synthesized IPECs have great potential to be used as pH-sensitive oral controlled DDS.
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