α-Enones in heterocyclic synthesis of indazole, thiazine, chromene and quinoline derivatives with their antimicrobial activities

Abstract

α-Enones 1a,b react additively with hydrazine hydrate, thiourea, diethyl malonate, malononitrile, as well as ethyl cyanoacetate. Simultaneous cyclisation of the resulting 1:1 adducts yields indazole, thiazine, chromene and quinoline derivatives. The structures of all the synthesised compounds were confirmed by micro analytical and spectral data. The antimicrobial activity of some of the synthesised compounds were tested.