Abstract
beta-endorphin, administered into the cerebral ventricles of rats, provokes a sequence of behavioural and electroencephalographic (EEG) responses similar to those observed with general anaesthetics used clinically. Initial behavioural and EEG excitation, motor incoordination and exaggerated responsiveness to sensory stimuli are followed by a stage of rigid immobility with maintenance of local reflexes (withdrawal, corneal) and EEG arousal in response to stimulation. Finally, there is immobility associated with both EEG and behavioural unresponsiveness to severely noxious stimuli. Such a state of unconsciousness with complete analgesia defines general anaesthesia. This state was completely and rapidly reversed by the specific opiate antagonist, naloxone. The induction of general anaesthesia by a water-soluble neurohormonal peptide acting at specific receptor sites has important implications for traditional theories of anaesthesia.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
