تأثير ويتامين E بر استرس اكسيداتيو كبدي ناشي از ايسكمي- پرفيوژن مجدد كليوي در موش سوري

Abstract

Introduction: Recent studies have reported that remote organs, such as liver are affected by renal ischemia reperfusion. Oxidative stress has been proposed as one of the causative factors of these damages. This study was designed to evaluate the protective effects of vitamin E on the liver oxidative stress after renal ischemia reperfusion (IR). Methods: Male mice were subjected to three groups (n=9): Sham operated, renal IR (45 min ischemia) and renal IR+Vitamin E (150 mg/kg trough feeding tube for 28 days) after 24 h of reperfusion. Animals were anesthetized and blood samples were obtained from the heart. Moreover, liver tissues were collected for tissue enzyme evaluation. Results: IR increased plasma concentration of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) and also decreased liver tissues superoxide dismutase (SOD) and catalase (CAT). Vitamin E consumption diminished plasma AST and ALT and increased SOD and CAT activity in liver tissues. Conclusion: These findings showed that vitamin E consumption prevented the IR-induced liver damage and preserved liver tissues antioxidant enzyme after IR-induced oxidative stress.