Abstract

This article discusses negative effects of vitamin D deficiency on low birthweight preterm and full-term newborns. Results of the studies on vitamin D provision to pregnant women and their newborn children are addressed. Vitamin D deficiency is highly prevalent in pregnant women and newborns. It was demonstrated that inadequate antenatal provision of a fetus with vitamin D may result in congenital rickets and neonatal seizures due to hypocalcemia in newborns and also accounts for increased rates of necrotic enterocolitis, bronchopulmonary dys-plasia, and impaired growth and development as well as higher risk of lower respiratory tract infections (i.e., bronchiolitis, pneumonia) during the first year of a child’s life. In addition, it was shown that persistent vitamin D deficiency in future years may be associated with recurrent respiratory infections, allergic (e.g., atopic dermatitis, asthma, etc.), autoimmune, endocrine, and psycho-neurological disorders. Preventive and therapeutic strategies for vitamin D deficiency in low birthweight preterm and full-term newborns since neonatal period are discussed.Keywords: vitamin D, vitamin D deficiency, calcidiol, low birthweight newborn, preterm newborn, full-term newborn.For citation: Zakharova I.N., Mal’tsev S.V., Zubkov V.V. et al. Vitamin D, low birthweight preterm and full-term newborns: time for a paradigm shift. Russian Journal of Woman and Child Health. 2020;3(2):142–148. DOI: 10.32364/2618-8430-2020-3-2-142-148.

Highlights

  • Результаты научных исследований, проведенных на рубеже XX–XXI вв., свидетельствуют об уникальных биологических свойствах витамина D, что позволило по-новому взглянуть на его физиологическую роль в организме

  • При этом выявлена корреляция между уровнем витамина D в организме матери и показателями развития костной ткани новорожденного, такими как длина бедренной кости, минеральный состав и площадь поперечного сечения большеберцовой кости [27]

  • Qin L.L., Lu F.G., Yang S.H. et al Does maternal vitamin D deficiency increase the risk of preterm birth: a meta-analysis of observational studies

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Summary

Introduction

Результаты научных исследований, проведенных на рубеже XX–XXI вв., свидетельствуют об уникальных биологических свойствах витамина D, что позволило по-новому взглянуть на его физиологическую роль в организме. Что дефицит витамина D наблюдается более чем у половины матерей и новорожденных [17,18,19,20]. Что дефицит витамина D у матери может быть связан с повышенным риском развития гипербилирубинемии у новорожденного [36].

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