ВИТАМИН D ПРИ РАЗЛИЧНОЙ ВОЗРАСТ-АССОЦИИРОВАННОЙ ПАТОЛОГИИ У ДОЛГОЖИТЕЛЕЙ И БОЛЬНЫХ ИБС В СТАРЧЕСКОМ ВОЗРАСТЕ

Abstract

Introduction. Vitamin D deficiency is associated with many pathological conditions. The elderly is at high risk of vitamin D deficiency due to their reduced ability to produce vitamin D precursors in the skin. Aim. To analyze 25-Hydroxycalciferol relationships with various clinical and laboratory parameters in centenarians and very elderly patients with coronary artery disease. Material and methods. This work was cross-sectional study. The study included 230 patients aged 76 to 99 years, hospitalized with the diagnosis of coronary heart disease. The concentration of 25-hydroxycalciferol was determined by immunochemiluminescent analysis. A 25-hydroxycalciferol level <10 ng/mL was considered as severe vitamin D deficiency, 10-19 as deficiency, 20-29 as insufficiency, and ≥30 ng/mL as normal. Results and discussion. The mean 25-Hydroxycalciferol concentration was 14.9+10.2 ng/mL. Only 7.5% of patients had normal 25-Hydroxycalciferol level, 12.3% - insufficiency, 43.6% - deficiency, 36.6% - severe vitamin deficiency. In centenarians the mean concentration of vitamin D was 12.9+9.9 ng/ml, in patients <90 years – 16.4+10.2 ng/ml (p=0.01). Significant positive correlations were registered between vitamin D level and hand grip strength measured by dynamometry (r=0.2; p=0.008) and the instrumental activity scale (r=0.1; p=0.03). The mean level of vitamin D in the group of patients with high risk of cognitive impairment was 11.2+5.8 ng/ml, with low risk of cognitive impairment – 20.8+18.5 ng/ml (p<0.0001). Negative correlations were registered between 25-Hydroxycalciferol level and the Morse fall scale (r=-0.2, p=0.03). Significant direct correlation between serum uric acid and vitamin D was registered (r=0.3; p=0.001). No significant relationships were found between vitamin D levels and bone mineral density in various parts of the skeleton, with the exception of the T-score in the lumbar spine in centenarians (р=0.004). Conclusion. The study results indicate presence of various relationships between 25-Hydroxycalciferol blood concentration and various clinical and laboratory parameters in centenarians and very elderly patients with coronary artery disease and, above all, with functional insufficiency, cognitive impairment and hyperuricemia.