Abstract
Evidence is accumulating for an important role of D-serine, a co-agonist of the NMDA receptor glycine site, in the pathogenesis of psychiatric disorders. According to various literature sources, D-serine may contribute to correcting cognitive impairments and negative symptoms in schizophrenia. Given the therapeutic potential of D-serine, it seems important to investigate its effect on experimental models of pathological behavior. This study was carried out on GC rats, proposed as a model of catatonic disorders, and Wistar rats, undisposed to catatonic reactions. In numerous studies, D-serine is used at fairly high doses, although it has been established that high doses of D-serine elicit adverse side effects. The goal of this work was to investigate the effect of low D-serine doses on the behavior of both GC rats and control Wistar rats in the light-dark box and elevated plus maze tests, as well as on their learning ability in the Barnes maze. It was found that intraperitoneal injection of 50 mg/kg D-serine had both anxiolytic and procognitive effects on Wistar rats. In GC rats, a D-serine dose of 100 mg/kg reduced locomotor activity in the elevated plus maze test, while at 50 mg/kg, D-serine reduced locomotor activity in the Barnes maze, but did not affect the latency to escape.
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