МИКРОБИОМ ПРИ НОВОЙ КОРОНАВИРУСНОЙ ИНФЕКЦИИ (COVID-19)

Abstract

The new coronavirus infection has been the leading public health problem in all countries for the past two years, causing enormous social and economic damage. The pathogenesis of COVID-19 infection continues to be studied, where the role of microflora of the respiratory and gastrointestinal tract (GIT) is considered to be important. The “intestine - lungs” functional axis, which ensures the interaction of the microbial communities of the respiratory tract and GIT, plays an important role in the immunopathogenesis of the COVID-19 infection, the development of inflammatory reaction in lung tissue and its subsequent restoration, as well as the formation of secondary bacterial complications. The intestinal infection with SARS-CoV-2 virus causes significant changes in the diversity and functional activity of intestine microbiota affecting negatively on the immune response patterns and maintenance of the colonization resistance of the mucous membranes. Summarizing the presented data of scientific publications on the problem of microbiome changes with the new coronavirus infection and the role of the “intestine - lungs” functional axis, the search for the modulation of the intestinal/respiratory microbiome seems promising with the purpose of not only preventing the progression of the disease, but also reducing of the duration of the disease and the severity of the symptoms of lung and GIT injury, as well as post-COVID symptoms prevention.