Abstract
β- C-Glycosiduronic acid quinones and β- C-glycosyl compounds have been synthesized as sugar-based PTP1B inhibitors. Benzoyl protected quinone derivatives ( 14 and 35) as well as aryl β- C-glycosyl compounds ( 18, 22, 23 and 34) showed IC 50 values of 0.77–5.27 μM against PTP1B, with compounds 18 and 23 bearing an acidic function being the most potent.
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