Abstract
The cell cycle of MGH-UI cells, a cultured human bladder carcinoma cell line, were analyzed at various time points after the treatment with static dose of Thio-TEPA. Immediately after the treatment TC (cell cycle time) prolonged by 32% of the untreated control, with a main effect in S phase. Fourty-eight hours later, that was an interval shorter than 2 cell cycle time, TC and TS reduced to approximately the same level as the control. However, TG1 was shorter and TG2 was longer as compared to the corresponding values of the control, indicating a slight accumulation of G2 cells in the cell cycle. Reexposure at this time point to a high concentration of the agent, which was equal to cidal dose for the untreated cells, induced a regrowth of the cells.The experimental results indicate that Thio-TEPA retains a certain sensitivity on the cell cycle phases and suggest that G2 and G1 keep a crucial role for kinetics of cell killing by the agent.
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