β cell function and insulin resistance in type 2 diabetic patients with short disease duration treated with different short term intensive glycemic control

Abstract

Objective To investigate the insulin resistance and β cell function in short disease duration and naive type 2 diabetic patients treated with oral hypoglycemic agents (OHA),insulin or combining insulin and OHA.Methods Ninety newly diagnosed and naive type 2 diabetic patients (the diabetic duration≤1 year) were randomly divided into three groups,treated with OHA,insulin or combining therapy separately.Each group included 30 cases and Was put on intensive glycemic control.The targets for glycemic control were fasting blood glucose less than 6.0 mmoL/L,and two hours postprandial blood glucose less than 8.0 mmoL/L,which were achieved in 7-10 days,and had been lasted for 2-4 weeks.Before and after intensive therapy,intravenous glucose tolerance test (IVGTT) was performed to calculate AUCIns0-10 min,Homa A and Homa B.Results After intensive treatment,AUCIns0-10 min and Homa B increased,but Homa A decreased in three groups.There were no differences among three groups.Condusion The same excellent improvement of insulin sensitivity and β cell function can be obtained by three ways of intensive glycemic treatment in short disease duration and naive type 2 diabetic patients. Key words: Type 2 diabetes mellitus; Intensive treatment; Intravenous glucose tolerance test; β cell function; Insulin resistance