Abstract
β-carotene (BC) is one of the best known and used bioactive compounds with antioxidant activity. In this work coprecipitation of BC with polyvinylpyrrolidone (PVP) by Supercritical Assisted Atomization (SAA) has been studied, to enhance BC bioavailability and to provide its protection against oxidation. Two solvents have been used: ethanol and a mixture acetone/ethanol 70/30 (v/v). In both cases SAA produced spherical and amorphous microspheres with d50 ranging between 0.42 and 0.84 μm using ethanol, and 0.28 and 0.48 μm using the solvent mixture. UV–vis analyses revealed a BC content up to 94% and high scavenging activities confirm that PVP is able to protect it from degradation. BC dissolution rate in a phosphate buffered saline solution (PBS) was up to 22 times faster than that of physical mixture. The major difference between coprecipitates was in their dissolution rate: it depended also on the kind solvent used, indicating a possible different internal particles organization during droplet drying.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
