Роль снижения экспрессии гена CACNA1C в развитии некоторых состояний в практике врача

Abstract

Тhe study of CACNA1C gene expression is relevant both in the practice of a physician and cardiologist, as well as an obstetrician-gynecologist, in psychiatry, neonatology, and gynecological oncology. The clinical effects of impaired expression of the CACNA1C gene depend on its penetrance and can determine such clinical conditions as cardiac arrhythmias and conduction, up to the development of sudden death, premature birth, arterial hypertension or hypotension, autism, schizophrenia. The relationship between the decrease in CACNA1C gene expression in smooth muscles and the development of genital prolapse, as well as the symptom complex “weakness of the stromal-muscular component”: arterial hypotension, 22.6–30%, myopia — 40.6%, violation of heart rhythm and conduction — 64.2% (sinus arrhythmia — 12.3%. WPW syndrome — 12.3%, early repolarization syndrome — 10.9%, incomplete blockade of the right bundle of His — 28.7%, mitral valve prolapse — 88%, varicose veins — 39.5%, pelvic floor protrusion and relaxation — 50%, joint hypermobility — 48.8%, grade 2 scoliosis — 33%, flat foot 3 degrees — 73.8%, hypotonic intestinal dysfunction — 50–60%, asthenic body type (30%), tendency to muscular asthenia, tendency to functional isthmic ikalnoy deficiency during pregnancy (23%), rapid and swift childbirth (37.6%). A study of the level of CACNA1C gene expression will help substantiate treatment tactics in a number of clinical conditions.