Abstract
Physiome, “physio”(life) plus “ome” (as a whole), is a study to provide a quantitative description of physiological dynamics and functional behavior of the intact organism (physiome project). We performed physiome study to clarify the roles of Ca2+ crosstalk between mitochondria–sarcoplasmic/endoplasmic reticulum in HL–1 cardiomyocytes and B lymphocytes, especially focusing on the mitochondrial Na+–Ca2+ exchanger NCLX, by combining cell physiological experiments and cell model simulations. It was revealed that NCLX–mediated Ca2+ supply to sarcoplasmic/endoplasmic reticulum is a key determinant for the generation of automaticity of HL–1 cells and the Ca2+ response to B cell receptor stimulation and chemotaxis in B lymphocytes.
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