Abstract
The key role of Bcl-2 (B-cell lymphoma) family proteins in the programmed cell death (PCD) process is reliably established, but particular molecular mechanisms of downregulation are still insufficiently clear. There are several hypotheses explaining the protective (Bcl-2, Bcl-xL) and proapoptotic (Bcl-x, и Bak) functions of Bcl-2 family proteins. This paper summarizes the available information concerning the molecular mechanism of action of pro- and antiapoptotic proteins of Bcl-2-family. In particular, an original hypothesis is put forward that homo- and heterodimerization of these proteins are the key events in the mechanism of Ca 2 + dependent homeostasis regulation.
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