Abstract
A novel TRH analog, γ-butyrolactone-γ-carbonyl-histidyl-prolinamide citrate (DN-1417) with very low TSH-releasing activity markedly increased motor activity in the mice, with and without reserpine administration. DN-1417 also promoted arousal from pentobarbital or ethanol sleep and from loss of consciousness induced by concussive head injury, and reversed hypothermia induced by pentobarbital and reserpine. Circling behavior was provoked by comparatively low doses of DN-1417 in mice with unilateral striatal lesion, and the effect was prevented by pimozide and α-methyl-p-tyrosine. The results indicate that DN-1417 is more potent and longer-acting than TRH in the CNS behavioral paradigms, and that some of the effects may be relevant to central monoaminergic systems.
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