Abstract
Electrophysiological studies have shown that β-bungarotoxin modifies the release of neurotransmitter from mammal ian motor-nerve terminals. In this paper we demonstrate that β-bungarotoxin can also inhibit calcium accumulation into sub-cellular fractions from rat brain at very low concentrations (2–8 pmoles toxin/mg protein). Since the calcium uptake which is inhibited has the characteristics of mitochondrial calcium accumulation (DNP-sensitivity, succinate stimulation), we conclude that the toxin affects the mitochondria. We suggest that the electrophysiological observations are consistent with direct or indirect inhibition by toxin of mitochondrial calcium uptake.
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