Abstract
(Received: June 26, 2014; Revised: October 8, 2014; Accepted: 13 October, 2014)Abstract : Bone marrow is a hematological and immunological organ that provides multiple immune cells, includingB lymphocytes, and thus plays a critical role in the efficacy of vaccine. We previously demonstrated that Bordetella(B.) bronchiseptica antigen has high immunogenicity in spleen cells, a peripheral immune organ. In this study, weinvestigated the immunogenicity of B. bronchiseptica antigen in bone marrow cells, a central immune organ. B.bronchiseptica antigen increased the cellular activity of bone marrow cells and significantly enhanced the productionof nitric oxide, IL-6, and TNF-α. Bone marrow cells primed with B. bronchiseptica antigen in vivo were harvested andstimulated with the same antigen in vitro. The stimulation of B. bronchiseptica antigen significantly increased the cellularactivity and proliferation rate of the primed cells. B. bronchiseptica antigen also greatly induced the production of antigen-specific antibody in the primed cells. Taken together, the present study demonstrated that B. bronchiseptica antigen canstimulate bone marrow cells, a central immune organ, and recall the immune response of the primed bone marrow cells.Keywords : antigen, Bordetella bronchiseptica, immune memory responses, stimulatory effects, vaccine
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