脂質と atherogenesity

Abstract

In order to elucidate the atherogenesis of serum lipids from the aspects of lipoproteins, determination of human serum lipoproteins, experimental atherosclerosis by hydroginated coconuts oil administration and observation of β-lipoproteins insudation into aortic wall of rabbits by immunohistochemical studies were performed.1) Serum low and very low density lipoprotein levels of atherosclerotic patients (myocardial infraction, argina pectoris, cerebral infarction) were significantly elevated as compared with those of matched controls. Contrarily, serum high density lipoprotein levels were significantly lower in the atherosclerotic patients.Those data suggest that atherogenesity from serum lipids may be affected by the increase of low and very low density lipoprotein concentrations and decrease of high density lipoprotein concentration. Furthermore, Atherogenic Index obtained by the liner-discriminant method suggests that the atherogenesis of very low density liporoteins may be stronger than that of low density lipoproteins.2) In the cholesterol fed rabbits, simple atheromatous plaques were observed in the aortic wall. On the other hand, in the hydroginated triglyceride fed rabbits, more severe regressive changes such as calcification were complicated.Lipid compositions of lipoproteins were different between cholesterol fed and hydroginated triglyceride fed rabbits. In the cholesterol fed rabbits, percentage of cholesterol in the very low density lipoprotein significantly increased as compared with that of control rabbits. Lipid compositions of lipoproteins of the triglyceride fed rabbits were almost same with those of control rabbits.Above mentioned results also suggest more severe atherogenesis of triglyceride than that of cholesterol.3) In the studies by the immunohistochemical technique, accumulations of β-lipoprotein in the aortic wall of rabbits were parallel with degree of hyper-lipoproteinemia and its duration.4) From the above mentioned results, it may be concluded the serum lipid have atherogenesity and extent of atherogenesity is associated with degree of hyperlipidemia and its duration.