Abstract
Several polymorphisms of the human β-adrenoceptor exist, some of which are associated with functional changes. The picture becomes even more complex when the strong linkage disequilibrium between certain polymorphisms is considered. A study in the New England Journal of Medicine investigated vasodilator responses to isoproterenol and desensitization in patients with three different genotypes for two common alleles at positions 16 and 27. The results indicated that the Glu27 polymorphism is associated with enhanced responsiveness to agonists, whereas the Arg16 polymorphism is associated with increased desensitization. The Glu27 polymorphism is found more often in white than African-American populations, and could contribute to the well-documented differences in vascular reactivity between the two racial groups. [Dishy, V. et al. (2001) New Engl. J. Med. 345, 1030–1035] AB
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