Abstract
Binding parameters of (−)-iodopindolol to β 2-adrenoceptors were determined on intact mononuclear cells in 41 untreated patients with different DSM-III subtypes of depression. Both maximal β-receptor density ( B max) and dissociation constant ( K d) were not significantly different between control and all depressed subjects. However, B max was significantly decreased in unipolar patients as compared to controls ( p < 0.001) whereas no significant difference was found in bipolar or dysthymic patients. In unipolar patients, a very strong association was found between B max values and the severity of the depression as assessed by the Hamilton Depression Rating Scale score ( r = −0.75; p < 0.005). This correlation was also highly significant in the entire depressed population ( r = −0.58; p < 0.0009). These results suggest that the lower number of β-adrenoreceptors in intact leukocyte cells of depressed patients is related to the depression severity.
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