Abstract
The autonomic and cardiovacular acitivity of N,N-dimethyldopamine (DMDA) was studied in the dog and rabbit. DMDA appears to be a postganglionic sympathetic α-adrenoceptor agonist since it consistently caused vasoconstriction in several isolated vascular beds, even in the presence of ganglionic blockade. The pressor activity of DMDA was attenuated by the α-adrenergic antagonist phentolamine. Calculated pA 2 values for phenotolamine against both DMDA and norepinephrine in isolated rabbit arteries were in close agreement. DMDA inhibits cardioaccelerator nerve stimulation induced chronotropic responses by a mechanism which appears to be α-adrenergic in the dog.
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