Abstract
BackgroundThe α-adducin Gly460Trp (G460W) gene polymorphism may be associated with susceptibility to essential hypertension (EH), but this relationship remains controversial. In an attempt to resolve this issue, we conducted a meta-analysis.MethodsTwenty-three separated studies involving 5939 EH patients and 5021 controls were retrieved and analyzed. Four ethnicities were included: Han, Kazakh, Mongolian, and She. Eighteen studies with 5087 EH patients and 4183 controls were included in the Han subgroup. Three studies with 636 EH patients and 462 controls were included in the Kazakh subgroup. The Mongolian subgroup was represented by only one study with 100 EH patients and 50 controls; similarly, only one study with 116 EH patients and 326 controls was available for the She subgroup. The pooled and ethnic group odds ratios (ORs) along with the corresponding 95% confidence intervals (95% CI) were assessed using a random effects model.ResultsThere was a significant association between the α-adducin G460W gene polymorphism and EH in the pooled Chinese population under both an allelic genetic model (OR: 1.12, 95% CI: 1.04–1.20, P = 0.002) and a recessive genetic model (OR: 1.40, 95% CI: 1.16–1.70, P = 0.0005). In contrast, no significant association between the α-adducin G460W gene polymorphism and EH was observed in the dominant genetic model (OR: 0.88, 95% CI: 0.72–1.09, P = 0.24). In stratified analysis by ethnicity, significantly increased risk was detected in the Han subgroup under an allelic genetic model (OR: 1.13, 95% CI: 1.04–1.23, P = 0.003) and a recessive genetic model (OR: 1.43, 95% CI: 1.17–1.75, P = 0.0006).ConclusionsIn a Chinese population of mixed ethnicity, the α-adducin G460W gene polymorphism was linked to EH susceptibility, most strongly in Han Chinese.
Highlights
Essential hypertension (EH) is one of the primary causes of cardiovascular diseases
Pooled analyses In the total Chinese population, there was a significant association between the a-adducin G460W gene polymorphism and essential hypertension (EH) under an allelic genetic model (OR: 1.12, 95% confidence intervals (95% CI): 1.04– 1.20, P = 0.002) and a recessive genetic model (OR: 1.40, 95% CI: 1.16–1.70, P = 0.0005)
No significant association between the aadducin Gly460Trp gene polymorphism and EH was observed in the dominant genetic model (OR: 0.88, 95% CI: 0.72–1.09, P = 0.24)
Summary
Essential hypertension (EH) is one of the primary causes of cardiovascular diseases. It is a polygenic hereditary disease with a complex pathogenesis that is strongly influenced by environmental and lifestyle factors. Previous studies have indicated that abnormal renal membrane ion transport might play a key role in the onset of EH [1]. Adducin regulates cellular signal transduction and cytolemma ion transport by modulating the surface expression of multiple transporters and pumps, including the Na+-H+ exchanger, Na+-K+-Cl2 cotransporter, and the sodium pump [2]. Regulation of renal Na+ transport by the adducin protein suggests that allelic variants of adducin may contribute to EH. The a-adducin Gly460Trp (G460W) gene polymorphism may be associated with susceptibility to essential hypertension (EH), but this relationship remains controversial. In an attempt to resolve this issue, we conducted a metaanalysis
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