α‐Acryloylamidoalkyl Sulfones in a Synthetic Approach for the Preparation of 6‐Alkyltetrahydropyridin‐2‐ones

Abstract

AbstractThe reaction of allylzinc bromides with α‐acryloylamidoalkyl sulfones represents a mild and straightforward entry to the corresponding homoallylamines. These dienyl compounds successfully proceeded in a ring‐closing metathesis reaction by treatment with Grubbs II catalyst to lead to 6‐alkyltetrahydropyridin‐2‐ones. Homoallylamino derivatives that contain a branched terminal alkene moiety preferentially proceeded in cross‐metathesis reaction to give the selective formation of N‐substituted fumaramides.