Abstract
Birch bark dry extract (BBDE) containing no less than 70% of betulin and betulin alone were compared with the reference drugs suprastin and claritine for their antiallergenic action. It is established that BBDE and betulin reduce by half the systemic anaphylactic reaction in guinea pigs immunized with ovalbumin from chicken egg white, their action being comparable with that of suprastin in mild and medium anaphylactic shock. The course of BBDE administration per os or intaperitoneally leads to a significant decrease in the content of IgE antibodies to ovalbumin in mice of various strains immunized in different regimens. The effect of BBDE on anaphylactic contraction of isolated guinea pig ileum samples was evaluated and showed no direct action upon the H1-receptors. Studies on models of pseudoallergenic reaction to concanavalin A in mice and carragenan-induced paw edema in rats showed that the anti-inflammatory action of BBDE is comparable with that of suprastin and claritine and is more pronounced than the effect of betulin.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
