Узкополосное оптическое излучение с длиной волны 540 нм в комплексном лечении прогрессирующей стадии псориаза

Abstract

Purpose . To define the effectiveness of photochromotherapy (PCT) with narrow-band optical radiation of wavelength 540 nm (NBOR λ = 540 nm) in the complex therapy of patients with psoriasis. Material and methods . 57 patients with the verified diagnosis were taken into the trial: common psoriasis, progressive stage, non-seasonal form. All patients were randomized by the random number table into 3 clinically comparable groups: Group 1 (18 patients) had standard therapy; Group 2 (24 patients) had standard therapy plus PCT (NBOR λ = 540 nm); Placebo Group 3 (15 patients) had standard medicamentous therapy plus simulated effect of photochromotherapy. PCT with NBOR λ = 540 nm (green light) was performed using therapeutic device “Spectrum LC” laser-LED (model 02) simultaneously with the standard medicamentous therapy for 10 days. The following research techniques were used: clinical examination, psoriasis area and severity index (PASI), pruritus index BRS (behavioral rating scores), questionnaires (Spielberg–Khanin anxiety scale, Dermatology Life Quality Index – DLQI), ultrasonic dermascanning. Results . The complex therapy with NBOR λ = 540 nm resulted in : decreased PASI index from 15.6 to 7.1 points; PASI 55 – a significant decrease in psoriatic plaque thickness ; improved quality of life by 3.8 points; 100% reduction in the increased anxiety and 100% pruritus control. Conclusion . PCT (NBOR λ = 540 nm) applied for the treatment of progressive psoriatic stage has a statistically significant positive effect at the clinical course of the disease and at parameters of the Dermatological Life Quality Index (DLQI) as well as at the parameters of personal and situational anxiety.