한국인 44명의 임상시험에 의한 새로운 위드마크 식 적용

Abstract

This study was conducted to understand alcohol kinetics for Koreans and to present reasonable parameters for the application of the Widmark equation. A total of 44 healthy adults(11 female and 33 male) was selected and assigned to drink 1 g of ethanol per kg body weight of individual within 1 hour. Blood samples were then collected every 15 min for the first 3 h, 30 min next 3 h, and 1 h last 9 h. All samples were analyzed by gas chromatography with a flame ionization detector(GC-FID) for blood alcohol concentration(BAC). The maximum BAC(Cmax) was 0.145 ± 0.028%(g/100 mL) in average under the controlled experimental condition. Alcohol elimination rates(β-slope) in average were 0.0185 ± 0.0025 %/h for male and 0.0211 ± 0.0025 %/h for female, respectively. Widmark’s factor(rho-factor, r) in average were 0.61 ± 0.060 L/kg for male and 0.56 ± 0.073 L/kg for female. The Widmark alcohol calculation for Koreans is suggested that 1) It cannot be argued about the absorption rate due to the diversity of drinking types 2) The rapid absorption phase is an average of 15 minutes after drinking and there is no significant change in the first 1 hour 3) If the BAC is less than 0.02% or within 90 minutes of the end of drinking, the back-calculation is not possible 4) Estimation of alcohol concentration should be calculated as decreasing from the start time of drinking 5) The elimination rate is 0.0192 ± 0.0027 %/h for drinking driver 6) Widmark's factor should be calculated individually based on height, weight, sex and age.